Polymorphisms in Metabolic Genes: Relevance for Human Susceptibility to Butadiene
نویسنده
چکیده
This speculation appears to be based solely on the range of variability of the various enzyme activities, as measured by in vitro analyses of enzyme kinetics, and does not take account of the abundant literature that deals with the metabolic and genotoxic consequences of these polymorphisms, as measured in human cells in vitro and metabolic and genotoxic biomarkers determined in vivo. The relevant literature is reviewed here.
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